Organophosphorus pesticide toxicology

The toxicity of each species can be different, most of them are highly toxic and highly toxic, and a few are low toxicity.

Some varieties have a toxic effect when used in combination, such as mixtures of malathion and trichlorfon, trichlorfon and azinphos.

Some varieties can be transformed to increase toxicity. For example, the toxicity of 1605 increases after oxidation, and trichlorfon is converted into dichlorvos in an alkaline solution, which is more toxic.

Organophosphorus pesticides (organophosphate pesticides) form phosphorylated cholinesterase with cholinesterase in the body. The activity of cholinesterase is inhibited, so that the enzyme cannot decompose acetylcholine, resulting in excessive accumulation of acetylcholine in tissues. Overexcites cholinergic nerves, causing muscarinic, nicotinic, and central nervous system symptoms. Phosphorylated cholinesterase generally "ages" after about 48 hours and is not easy to recover.

Some ester hydrocarbyl and aromatic hydrocarbyl phosphate compounds still have delayed neurotoxicity, which is caused by organophosphorus pesticides inhibiting neuropathy target esterase (neurotoxic esterase) in vivo and causing it to "age", causing delayed neurotoxicity. Neuropathy. This toxic effect has nothing to do with cholinesterase activity.

Organophosphorus pesticides in the form of sustained-release microcapsules have a longer duration of action.